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Master of Science in
Biological Sciences

Meet our Graduate Faculty

Dr. Britto P Nathan, Professor and Graduate Coordinator

Office: 2154 - Life Science Annex
Phone: 217-581-6891
Office Hours: Mondays 11am -1pm, Wednesdays & Fridays 12pm -1pm
               Course Information                          Days & Time         Location
BIO 1100-003 & 004 General Biology  M W F 2pm -2:50pm   2080
BIO 1100-003 LAB                                      R 11am -1:50pm          2140 
BIO 1100-004 LAB                                      R 2pm -4:50pm            2140

Dr. Nathan's Web Site


Dr. Nathan's research centers around neuroscience with special interest in neurological diseases. His current research is aimed at understanding the pathological pathways that lead to death of brain cells in aging humans, and predisposes them to dementia such as Alzheimer's disease. A wide range of molecular, biochemical, and cellular techniques are used in his laboratory. He has received funding from the Alzheimer's Association and the National Institute of Health, and has published in several journals including Science.

Selected Publications

A. Barsukova*, R.G. Struble, B.P. Nathan. Isoform-specific effects of apolipoprotein E on mircoglial activation in cortical and microglial cultures from adult mouse brain, Journal of neurodegeneration and regeneration, In Press.

Nwosu I, Gairhe* S, Struble RG, Nathan BP. Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb. Neurosci Letters, 441(3):282-5, 2008.

Struble, R.G., Cady, C., Nathan, B.P., McAsey, M.E. Apolipoprotein E may be a critical factor in hormone therapy neuroprotection. Frontiers in Bioscience, 5387-5405, 2008.

Nathan, B.P., Nannapaneni*, S., Gairhe*, S., Nwosu*, I., Struble, R.G. The distribution of apolipoprotein E in mouse olfactory epithelium. Brain Research, 1137, 78-83, 2007.

Cheng, X., McAsey, M., Li, M., Randall, S., Cady, C., Nathan, B.P, Struble, R.G. Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain. Neuroscience Letters, 417(1):50-54, 2007.

Struble RG, Afridi S, Beckman-Randall S, Li M, Cady C, Nathan B, McAsey ME. Neocortical and Hippocampal Glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycle. Neuroendocrinology, 83: 325-335, 2006.

McAsey, M.E., Cady, C., Jackson, L.M., Li, M., Randall, S., Nathan, B.P., Struble, R.G., Time course of response to estradiol replacement in ovariectomized mice: brain apolipoprotein E and synaptophysin transiently increase and glial fibrillary acidic protein is suppressed. Experimental Neurology, 197(1), 197-205, 2006.

Struble RG, Nathan BP, Cady C, Cheng X, McAsey M. Estradiol regulation of astroglia and apolipoprotein E: An important role in neuronal regeneration. Experimental Gerontology, 10, 2006

Selected Conference Presentations

Invited speaker on “Interaction of apoE with estrogen in Alzheimer’s disease” Alzheimer’s Center, Southern Illinois University, Medical School, Springfield, IL, 2007.

Poster Presentations Poster Presentation on “Impact of apoE deficiency on regeneration of olfactory receptor neurons post injury in mice” at Annual Meeting of Association for Chemoreception Sciences, Sarasota, FL, 2007.

Invited Speaker on “ApoE and Alzheimer’s disease” at Department of Molecular and Integrative Physiology, University of Illinois, IL, 2006.

A Cell Culture System For Studying the Role of ApoE in Alzheimer’s Disease.  2003.

Behavioral Studies on an Animal Model for Alzheimer’s Disease.  2003.

* = Student Author

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Contact Information

Dr. Britto P Nathan
Professor and Graduate Coordinator

2154 Life Science Annex
Life Sciences Building
600 Lincoln Avenue
Charleston, IL 61920

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