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Dr. Gary A Bulla

Dr. Gary A Bulla

Professor and Associate Chair

Office: 2072 - Life Science
Phone: 217-581-3499
Email: gabulla@eiu.edu

Dr. Bulla's Web Site

Dr. Bulla's research focuses on mechanisms controlling mammalian gene expression and development. Three areas of interest include: 1) Activation and silencing of hepatic gene expression 2) The link between hepatic gene expression and cellular response to signaling molecules (including NF-kB) 3) The role of hepatic transcription factor mutations in the development of diabetes. His research has been funded by the National Institutes of Health and the National Science Foundation.   


Frequently Taught Courses

Bio1100 General Biology
Bio3120 Molecular and Cellular Biology
Bio3622 Embryology
Bio4751 Advanced Molecular and Cellular Biology

Education

B.S., Microbiology, Colorado State University, Fort Collins, Colorado, 1981
M.S., Microbiology, Colorado State University, Fort Collins, Colorado, 1983
Ph.D., Microbiology, University of Colorado, Health Sciences Center, Denver, Colorado, 1988

Postdoctoral Fellow, Program in Molecular Medicine, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 1988-1993. Research area: Genetic and molecular control of a1-antitrypsin gene expression in somatic cell and microcell hybrids as a model for tissue-specific gene expression.

Research

Our research focuses on mechanisms controlling mammalian gene expression and development. Three areas of interest include: 1) Activation and silencing of hepatic gene expression 2) The link between hepatic gene expression and cellular response to signaling molecules (including NF-kB) 3) The role of hepatic transcription factor mutations in the development of diabetes. This research has been funded by the National Institutes of Health and the National Science Foundation.

Selected Publications

Bulla GA1, *Aylmer AM, *Dust, AL, *Kurkewich, JL, *Mire, LK, *Estanda,A. Genome-wide Analysis of Hepatic Gene Silencing in Hepatoma Cell Variants Genomics (In Press) 2012.

Bulla, GA1, *Luong, Q, *Shrestha S, Reeb S,*Hickman S. Genome-wide Analysis of Hepatic Gene Silencing in Mammalian Cell Hybrids. Genomics 96:323-332, 2010.

Reidy MR, *Ellis JA *Schmitz EK, *Kraus DM, Bulla GA. Protection from LPS-mediated apoptosis of dedifferentiated hepatoma cells is independent of NF-kB activation. Bioscience Reports 27:235-46, 2007.

Reidy MR, *Ellis JA *Schmitz EK, *Kraus DM, Bulla GA. Protection from LPS-mediated apoptosis of dedifferentiated hepatoma cells is independent of NF-kB activation. Bioscience Reports 27:235-46, 2007.

Bulla GA, *Kraus,DM. Dissociation of the Hepatic Phenotype from HNF4 and HNF1a Expression. Bioscience Reports, 24:595-608, 2005.

Schmitz EK, *Kraus DM, Bulla GA. Tissue-specificity of apoptosis in hepatoma-derived cell lines. Apoptosis, 9:369-375, 2004.

Kraus DM, Bulla GA. Defective NF-kB signaling in dedifferentiated hepatoma cells. Somat. Cell. Molec. Genet., 27:275-286, 2002.

Kladney, RD, *Cui C, Bulla, GA, Fimmel CJ.Disease- and cell-specific expression of GP73, a novel Golgi protein: evidence for virus-dependent and -independent regulation in hepatocytes. Hepatology, 35:1431-1440, 2002.

Bulla GA, *Givens E, *Brown S, *Oladiran B, *Kraus D. Protection of dedifferentiated hepatoma variant cells from LPS-induced apoptosis by restoration of hepatic gene expression. J. Cell Science, 114:1205-1212, 2001.

Kladney R, Bulla GA, Guo, L, Mason AL, Tolleffson AE, Simon DJ, Koutoubi Z, Fimmel C. GP73, a novel Golgi-localized protein upregulated by viral infection. Gene 249:53-65, 2000.

Khalkhali-Ellis Z, Bulla GA, Schlesinger LS, Kirschmann DA Moore TL, Hendrix MJC. C1q containing immune complexes purified from sera of juvenile rheumatoid arthritis patients mediate IL-8 production by human synoviocytes: Role of C1Q receptors. J. Immunol. 163:4612-4620, 1999.

Bulla GA. Extinction of a-antitrypsin gene expression in somatic cell hybrids is independent of loss of HNF1a and HNF4 in somatic cell hybrids. Nucl. Acids Res. 27: 1190-1197, 1999.

Bulla GA, Batanian J, *Young H, *Bradley N, *Kazi N, Haddad, B. Rescue of the HNF4 to HNF1a pathway in hepatoma variant cells containing human chromosomal 12. Genomics 54:398-407, 1998.

Bellezzo JM, Leingang KA, Bulla GA, Britton RS, Bacon BR, Fox ES. Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants J. Lab. Clin. Med. 131:36-44, 1998.

Bulla GA. Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway Somat. Cell. Molec. Genet. 23: 185-202, 1997.

Selected Conference Presentations

*Aylmer, CM., Kurkewich, J, and , Bulla, GA. Identifying candidate genes involved in hepatic gene silencing in hepatoma variants. Poster presentation at Illinois State Academy of Science conference, March 30-31 2012, Knox College, Galesberg, IL.

*Estanda, A, and Bulla, GA. Identification of candidate genes driving liver function using whole genome microarrays. Oral presentation at Illinois State Academy of Science conference, March 30-31 2012, Knox College, Galesberg, IL.

Lopez, A., Roe, Allixandra L., and Bulla, GA. Chromosomal Mapping of Genes Silenced in Rodent Cell Hybrids. Poster presentation at Illinois State Academy of Science conference, April 8-9, 2011, Eastern Illinois University, Charleston, IL.

Bulla, GA, *Luong, Q, *Shrestha S, Reeb S,*Hickman S. Genome-wide Analysis of Hepatic Gene Silencing in Mammalian Cell Hybrids. Poster presentation at the Keystone Symposium Mechanisms and Biology of Silencing held in Monterey, CA March 20-25, 2011.

*Allen, K, and Bulla, GA. Analysis of transcription factor promoter binding in rat hepatoma/fibroblast hybrids. Poster presentation at Illinois State Academy of Science conference, April 9-10, 2010, Millikin University, Decatur, IL.

*Dust, A and Bulla, GA. Genome-wide analysis of gene silencing in mammalian cell, hybrids. Poster presentation at Illinois State Academy of Science conference, April 9-10, 2010, Millikin University, Decatur, IL

*Hickman, S and Bulla, GA. Genome-wide analysis of gene silencing in mammalian cell, hybrids. Oral presentation at Illinois State Academy of Science conference, April 6-7, 2009, Illinois State University, Normal, IL Best oral presentation award- Cell/Molec division.

*Angle, JC and Bulla, GA. Analysis of transcription factor promoter binding in rat hepatoma/fibroblast hybrids. Poster presentation at Illinois State Academy of Science conference, April 6-7, 2009, Illinois State University, Normal, IL 2nd place, poster presentation award- Cell/Molec division.

Hickman, S and Bulla, GA. Genome-wide analysis of gene silencing in mammalian cell, hybrids. Poster presentation at 100th Annual Illinois State Academy of Science conference, April 4-5, 2008, University of Illinois, Champaign, IL.

Angle, JC and Bulla, GA. Analysis of transcription factor promoter binding in rat hepatoma/fibroblast hybrids. Poster presentation at 100th Annual Illinois State Academy of Science conference, April 4-5, 2008, University of Illinois, Champaign, IL.

Hickman, S and Bulla, GA. Genome-wide analysis of gene silencing in mammalian cell, hybrids. Poster presentation at Phi Sigma Biological Research Symposium , April 18, 2008, Illinois State University, Normal, IL.

Angle, JC and Bulla, GA. Analysis of transcription factor promoter binding in rat hepatoma/fibroblast hybrids. Poster presentation Phi Sigma Biological Research Symposium, April 18, 2008, Illinois State University, Normal, IL.

Stenzlik, MJ, Bjornbak, LR, Hagstrom LJ and Bulla, GA. ChIP analysis of hepatic gene silencing. Phi Sigma Biological Research Symposium, Illinois State University, April 13, 2007.

Roberts, T, Luong, V, Imburgia, AJ Tschampa, JJ and Bulla, GA Molecular Analysis Of Hepatic Gene Silencing. Poster presentation at 17th Annual Student Research Conference, Eastern Illinois University, Charleston, IL March 24-25, 2006.

Bulla, GA, Reidy, MR, Ellis, JA, Schmitz*, EA and Kraus, DA. Apoptosis of Dedifferentiated Hepatoma cells is Independent of NF-icB Activation in Response to LPS. Poster presentation at FASEB International Conference on Mechanisms of Liver Growth and Development and Disease. August 2006. Snowmass, Colorado.

Reidy, MR and Bulla, GA. Inhibition of Cellular Signaling Pathways Induces Apoptosis in Liver-Derived Cell Lines. Oral presentation at 17th Annual Student Research Conference, Eastern Illinois University, Charleston, IL March 24-25, 2006.

Oakley, H. and Bulla, G.A. (2005)
Fixation optimization of hepatoma cells for combined β-gal and GFP expression analysis.

Bulla, GA, Schmitz*, EA and Kraus*, DA. Tissue-Specificity of Apoptosis In Hepatoma-Derived Cell Lines. Poster presentation at FASEB Conference on Mechanisms of Liver Growth and Development and Disease. August 2004. Snowmass, Colorado.

Bulla, GA. Tissue-Specificity Of Apoptosis In Hepatoma-Derived Cell Lines. Oral presentation at the 96th Annual Illinois State Academy of Science conference, April 1-3, 2004, Charleston, IL.

Tian*, L and Bulla GA. Effect Of Coactivators And Chromatin Remodeling In Reactivation of Silenced Genes. Poster presentation at the 96th Annual Illinois State Academy of Science conference, April 1-3, 2004, Charleston, IL.

* indicates that author was a student (undergraduate or graduate) 

Funding & Grants

Current
National Science Foundation RUI (Research in Undergraduate Institutions) grant proposal. 2-1-09 through 1-31-13. “Whole-genome Analysis of Hepatic Gene Silencing”  P.I.- Gary A. Bulla.   $150,000.

Council on Faculty Research Award2012-13 “Searching for Master Regulators of
Liver Function”  $4640.

Past:
Leukemia Society of America Postdoctoral Fellowship, “Molecular analysis of cell-type-specific gene repression”: Principal Investigator: Gary A. Bulla, Sponsor: R.E.K. Fournier. Period of support: 7/1/89 – 6/30/92; total direct costs: $70,500.
                                   
Fleur-Di-Lis Award of Saint Louis University, "Genetic and molecular analysis of liver specification"; Principal Investigator: Gary A. Bulla; effort: 50%; period of support: 7/1/94 - 6/30/96; total direct costs; $20,000

NIH Grant # R29 DK48231-01A1, "Genetic and molecular analysis of liver specification"; Principal Investigator: Gary A. Bulla; effort: 50%; entire period of support: 5/1/95 - 4/31/00; total direct costs: $350,000.  

Interim Research Support, St. Louis University School of Medicine.Principal Investigator: Gary A. Bulla; Period of support: 5/1/00 - 4/31/01$9,035

Interim Research Support, St. Louis University School of Medicine.Principal Investigator: Gary A. Bulla; Period of support: 5/1/00 - 4/31/01$8,413

Veteran’s Administration Grant, “A novel hepatocyte membrane protein induced by  viral hepatitis”.  Principal Investigator: Claus Fimmel, MD. Funds for supplies and a graduate assistantship as part of collaboration with Gary Bulla, PhD. Entire period of support- 10/1/99 – 09/30/03; direct costs: $406,373.

Council on Faculty Research (CFR) Award “Type 2 Diabetes: Role of HNF1aand HNF4adefects”. Investigator: Gary A. Bulla, PhD. Period of support: 10/1/02  - 8/30/03. Total costs: $5000.

Council on Faculty Research (CFR) Award “Type 2 Diabetes: Role of HNF1aand HNF4adefects”.     (Summer grant 2003) $4000.

Seed grant Award, College of Sciences, January 28, 2004. $1000.

Council on Faculty Research (CFR) Award  “Activation of Silent Genes by Preventing DNA and Histone Modification”.          (Summer grant 2004) $4000.

Council on Faculty Research Award 2004-05.  “Mechanisms of Liver cell Death due to Bacterial Infection”. $4750.

College of Science Small Grant Award 2005. Travel grant.  $500

Redden Fund Grant Award. Gary Bulla and Gordon Tucker. Purchase of two digital eyepiece cameras for classroom instruction. $1,150.

Council on Faculty Research Award 2005-06.  “Mechanisms of Liver cell Death due to Bacterial Infection”. $3600.

Seed grant Award, College of Sciences, Principal Investigator: Gary A. Bulla, February 3, 2006. $1000.

Sigma Xi Grant-in-Aid awarded to Jun Ma (MS student). March 2006, $1000.

Council on Faculty Research (CFR) Award  “Identifying mechanisms of gene silencing”. (Summer grant 2006) $4000.

Council on Faculty Research Award 2006-07.  “Identifying mechanisms of gene silencing”. $3293.

Council on Faculty Research Award.  “Identifying mechanisms of gene silencing”. (Summer grant 2007) $4000.

Proposal Initiative Fund.  2007 “Molecular analysis of hepatic gene silencing”. $6400.

Council on Faculty Research Award.  “Genome-wide Analysis of Gene Silencing” (Summer grant, 2008) $4000.

Council on Faculty Research Award2008 “Whole genome analysis of hepatic gene silencing”. $4360.

Community

Undergraduate students conducting research  (2004 to present)

2012                         Caitlin Aylmer, Leon Mire, Adelle Dust, Jeff Kurkewich
2011                         Caitlin Aylmer, Leon Mire, Adelle Dust, Jeff Kurkewich
2010                         Dennis Tburzi, Andy Lopez, Allixandra Roe, Rachel Daugherty
2009                         Andy Lopez, Audra Dust, Kerstin Allen
2008                         Charelle Barksdale,  Audra Dust, Kerstin Allen
2007                         Lydia Bjornbak, Laura Hagstrom, Mallory Stenzlik, Jordan Angle, Michael  
                                   Hughes, Mandy Walker, Kyle Ingram, Carolyn Dundon,
2006                         Thomas Roberts, James Reynolds,  Jessica Tschampa, Laleh Moazimi, Vince
                                   Leong, Anthony, Imburgia, Mallory Stenzlik, Mark Klepacki, Eric Dust, Sarah
                                  Travis
2005                         Stephen Clark, Eric Dust, Laleh Moazimi, Vince Leong, Tom Roberts, Sheena
                                  James u
2004                         Hillary Oakley, Paula Schumacher and Chrissy Kamide, undergraduate  
                                  research


2004 Achievement and Contribution Award, outstanding contribution to the University Eastern Illinois University 2004 Graduate Dean’s Award of Excellence in Research (Eastern Illinois University)
2004 Panhellenic Faculty Member of the Month (October)



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